Fig. 6

Burst firing rates in TN animals following optogenetic stimulation (a). Significant changes were observed in the TN-Opto-CGRP and TN-Opto-PBS groups. *, p < 0.05; **, analysis of variance (ANOVA). b, c Peri-event raster histogram of VPM neuron responses in the TN-Opto-CGRP and TN-Opto-PBS groups, respectively. VPM firing rates decreases during optical stimulation. Bin size = 50 ms. d, e Instantaneous firing frequency for VPM neurons in TN-Opto-CGRP and TN-Opto-PBS rats, respectively